Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 5/20 | 0.36 |
| ▸ | HTR1B | P28222 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7514066 | 0.89 | HTR1A (0.47) | HTR1AMTNR1AMTNR1BHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7515525 | 0.87 | HTR1A (0.46) | HTR1AMTNR1AMTNR1BHTR1DHTR1B | |
| Fumaric Acid SCHEMBL7514859 | 0.84 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHSD17B10HTR1D | |
| Fumaric Acid SCHEMBL7515760 | 0.84 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHSD17B10HTR1D | |
| Succinic Acid SCHEMBL7517288 | 0.84 | HTR1A (0.45) | HTR1AMTNR1AMTNR1BHTR1DHTR1B | |
| Maleic Acid SCHEMBL7514854 | 0.84 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHSD17B10HTR1D | |
| Propionic Acid SCHEMBL7514987 | 0.83 | HTR1A (0.49) | HTR1AMTNR1AMTNR1BHTR1DHTR1B | |
| Oxalic Acid SCHEMBL10340260 | 0.82 | MAOA (0.43) | HTR1AMTNR1AMTNR1BDRD2 | |
| SCHEMBL8892925 | 0.82 | HTR1A (0.41) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL8891420 | 0.80 | MTNR1A (0.52) | HTR1AMTNR1AMTNR1BCYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5462962-A | Administering to mammals to selectively block biological receptors to treat anxiety or depression | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0392768-B1 | Tetrahydrobenz[C,D] indole serotonin agonists | LILLY CO ELI (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5204340-A | Anxiolytic agents; antidepressants; consumptive disorders,e.g. obesity, alcoholism and smoking; sexual dysfunction | ELI LILLY AND COMPANY (US) | 1993-04-20 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0392768-A1 | Tetrahydrobenz[C,D] indole serotonin agonists | ELI LILLY AND COMPANY (US) | 1990-10-17 | — | — | EP | disclosed |