Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891546 | 0.82 | HTR1A (0.47) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL7514066 | 0.82 | HTR1A (0.47) | HTR1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7515525 | 0.81 | HTR1A (0.46) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL10340613 | 0.78 | MAOA (0.48) | HTR1AMTNR1AMTNR1BMAOA | |
| SCHEMBL8891299 | 0.76 | HTR1A (0.54) | HTR1A | |
| Fumaric Acid SCHEMBL7514859 | 0.76 | HTR1A (0.42) | HTR1AMTNR1AMTNR1B | |
| Maleic Acid SCHEMBL7514854 | 0.76 | HTR1A (0.42) | HTR1AMTNR1AMTNR1B | |
| Succinic Acid SCHEMBL7517288 | 0.76 | HTR1A (0.45) | HTR1AMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL7515760 | 0.76 | HTR1A (0.42) | HTR1AMTNR1AMTNR1B | |
| SCHEMBL23261875 | 0.75 | MAP3K14 (0.39) | HTR1AMTNR1AMTNR1BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5462962-A | Administering to mammals to selectively block biological receptors to treat anxiety or depression | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0392768-B1 | Tetrahydrobenz[C,D] indole serotonin agonists | LILLY CO ELI (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5204340-A | Anxiolytic agents; antidepressants; consumptive disorders,e.g. obesity, alcoholism and smoking; sexual dysfunction | ELI LILLY AND COMPANY (US) | 1993-04-20 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |