Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | HTR1E | P28566 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7514859 | 1.00 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| Maleic Acid SCHEMBL7514854 | 1.00 | HTR1A (0.42) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| SCHEMBL7514066 | 0.92 | HTR1A (0.47) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| Hydrochloric Acid SCHEMBL7515525 | 0.91 | HTR1A (0.46) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| Succinic Acid SCHEMBL7517288 | 0.88 | HTR1A (0.45) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| Propionic Acid SCHEMBL7514987 | 0.87 | HTR1A (0.49) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| SCHEMBL8891546 | 0.84 | HTR1A (0.47) | HTR1AMTNR1AMTNR1BHTR1BHTR1D | |
| Maleic Acid SCHEMBL9238804 | 0.84 | MTNR1A (0.46) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| Fumaric Acid SCHEMBL9238809 | 0.84 | MTNR1A (0.46) | HTR1AMTNR1AMTNR1BHTR1BHTR7 | |
| Maleic Acid SCHEMBL7511768 | 0.80 | HTR1A (0.37) | HTR1AMTNR1AMTNR1BHTR1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0285278-B1 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| EP-0285278-A2 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1988-10-05 | — | — | EP | disclosed |
| US-4745126-A | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1988-05-17 | — | — | US | disclosed |