Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | APEX1 | P27695 | 2/20 | 0.32 |
| ▸ | RAD52 | P43351 | 2/20 | 0.32 |
| ▸ | GAPDH | P04406 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7530143 | 0.90 | TYR (0.44) | HMGCRESR1ESR2ALOX5MAPT | |
| SCHEMBL7529793 | 0.83 | ALOX15 (0.35) | ESR1ESR2MAPTLMNAMEN1 | |
| SCHEMBL7521976 | 0.81 | ESR1 (0.36) | HMGCRESR1ESR2ALOX5MAPT | |
| SCHEMBL27498599 | 0.75 | ALOX5 (0.42) | HMGCRESR1ESR2ALOX5MAPT | |
| SCHEMBL1760537 | 0.75 | HMGCR (0.64) | HMGCRESR1ESR2ALOX5MAPT | |
| SCHEMBL7515172 | 0.73 | TYR (0.40) | ESR1ALOX5MAPTLMNAHIF1A | |
| SCHEMBL8573280 | 0.72 | DHFR (0.35) | HMGCRESR1ESR2ALOX5PTPN1 | |
| SCHEMBL7519174 | 0.72 | HMGCR (0.47) | HMGCRESR1ESR2ALOX5MAPT | |
| SCHEMBL11840310 | 0.71 | HMGCR (0.59) | HMGCRESR1ESR2ALOX5MAPT | |
| SCHEMBL9744700 | 0.71 | TYR (0.49) | HMGCRALOX5MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |