Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515172 | 0.92 | TYR (0.40) | ESR1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL7517847 | 0.86 | MAPT (0.35) | ESR1ESR2KDM4EHPGDHSD17B10 | |
| SCHEMBL27496913 | 0.81 | ALOX5 (0.37) | ESR1ESR2HMGCRKDM4EHPGD | |
| SCHEMBL7514714 | 0.81 | HMGCR (0.42) | ESR1ESR2HMGCRKDM4EHPGD | |
| SCHEMBL8573273 | 0.78 | ALOX5 (0.35) | ESR1ESR2MAPTALOX5RAB9A | |
| SCHEMBL7526680 | 0.77 | ESR1 (0.39) | ESR1ESR2HMGCRKDM4EHPGD | |
| SCHEMBL8441756 | 0.75 | MAPT (0.38) | ESR1ESR2KDM4EHPGDHSD17B10 | |
| SCHEMBL7530143 | 0.73 | TYR (0.44) | ESR1ESR2HMGCRKDM4EHPGD | |
| SCHEMBL7526756 | 0.71 | MAPT (0.36) | ESR1ESR2KDM4EHPGDHSD17B10 | |
| SCHEMBL8573285 | 0.70 | TYR (0.36) | ESR1ESR2KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |