Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 4/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7514714 | 0.83 | HMGCR (0.42) | ALOX15ESR1ESR2MCL1KDM4E | |
| SCHEMBL7520118 | 0.81 | ESR1 (0.36) | ALOX15ALOX12ESR1ESR2MCL1 | |
| SCHEMBL7530143 | 0.80 | TYR (0.44) | ALOX15ESR1ESR2KDM4EMAPT | |
| SCHEMBL7517847 | 0.80 | MAPT (0.35) | ALOX15ALOX12ESR1ESR2KDM4E | |
| SCHEMBL8745976 | 0.77 | ALOX15 (0.42) | ALOX15ALOX12ESR1ESR2MCL1 | |
| SCHEMBL27517774 | 0.74 | ESR1 (0.43) | ESR1ESR2MCL1MAPTALDH1A1 | |
| SCHEMBL7520582 | 0.74 | ESR1 (0.33) | ALOX15ALOX12ESR1ESR2KDM4E | |
| SCHEMBL1760478 | 0.73 | ALOX15 (0.54) | ALOX15ALOX12ESR1ESR2MCL1 | |
| SCHEMBL8575917 | 0.70 | GABRA1 (0.39) | MAPTALDH1A1POLBHTTHPGD | |
| SCHEMBL6040093 | 0.69 | ALOX15 (0.56) | ALOX15ALOX12ESR1ESR2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |