Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.48 |
| ▸ | MMP2 | P08253 | 11/20 | 0.48 |
| ▸ | MMP3 | P08254 | 6/20 | 0.48 |
| ▸ | MMP1 | P03956 | 4/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454044 | 0.94 | MMP2 (0.49) | MMP13MMP2MMP3MMP1MMP8 | |
| SCHEMBL7513672 | 0.85 | MMP13 (0.59) | MMP13MMP2MMP3MMP1MMP8 | |
| SCHEMBL7901564 | 0.82 | MMP13 (0.44) | MMP13MMP2MMP3MMP1TDP1 | |
| SCHEMBL7450645 | 0.80 | MMP13 (0.44) | MMP13MMP2MMP3MMP1MMP8 | |
| SCHEMBL7509339 | 0.78 | MMP13 (0.61) | MMP13MMP2MMP3MMP1MMP8 | |
| SCHEMBL7454038 | 0.78 | MMP13 (0.74) | MMP13MMP2MMP3MMP1MMP8 | |
| SCHEMBL7516045 | 0.77 | MMP13 (0.65) | MMP13MMP2MMP3MMP1MMP8 | |
| SCHEMBL7595438 | 0.77 | MMP13 (0.57) | MMP13MMP2MMP3MMP1KMT2A | |
| SCHEMBL7509695 | 0.75 | MMP2 (0.58) | MMP13MMP2MMP3MMP1MMP8 | |
| SCHEMBL7898403 | 0.75 | MMP2 (0.45) | MMP13MMP2MMP3MMP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165501-A1 | ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6197770-B1 | ENZYME INHIBITORS; ANTIARTHRITIC AGENTS; BONE DISORDERS | THE PROCTER & GAMBLE CO. | 2001-03-06 | — | — | US | disclosed |
| WO-2000051975-A1 | ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-08 | — | — | WO | disclosed |