Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519331 | 0.91 | NPSR1 (0.32) | NR1I2ALDH1A1LMNACYP2C9MIF | |
| SCHEMBL7521149 | 0.86 | HSP90AA1 (0.34) | NR1I2ALDH1A1LMNACYP2C9MIF | |
| SCHEMBL7518999 | 0.84 | ALDH1A1 (0.33) | ALDH1A1ALOX15 | |
| SCHEMBL7526671 | 0.81 | GABRA1 (0.35) | NR1I2ALDH1A1LMNACYP2C9MIF | |
| SCHEMBL7526427 | 0.79 | ALDH1A1 (0.37) | NR1I2ALDH1A1LMNACYP2C9MIF | |
| SCHEMBL7525374 | 0.78 | ALDH1A1 (0.36) | NR1I2ALDH1A1LMNACYP2C9MIF | |
| SCHEMBL7521517 | 0.76 | ALOX15 (0.34) | ALDH1A1CYP2C9TYRALOX15HTT | |
| SCHEMBL8441588 | 0.75 | P4HB (0.34) | — | |
| SCHEMBL7521636 | 0.74 | NR1I2 (0.33) | NR1I2ALDH1A1LMNACYP2C9MIF | |
| SCHEMBL7523464 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |