Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 10/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.31 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521009 | 0.91 | VCAM1 (0.37) | VCAM1GAAALOX15CALM1 | |
| SCHEMBL7522609 | 0.86 | CALM1 (0.33) | VCAM1GAAALDH1A1MAPTCALM1 | |
| SCHEMBL7518758 | 0.84 | VCAM1 (0.47) | VCAM1LTB4R | |
| SCHEMBL7527917 | 0.80 | VCAM1 (0.40) | VCAM1GAAALOX15 | |
| SCHEMBL7522270 | 0.77 | GAA (0.37) | VCAM1GAA | |
| SCHEMBL7525872 | 0.76 | VCAM1 (0.36) | VCAM1GAAALDH1A1MAPK1LTB4R | |
| SCHEMBL7524217 | 0.74 | VCAM1 (0.37) | VCAM1GAAALDH1A1MAPTRAB9A | |
| SCHEMBL7523700 | 0.73 | NR1H4 (0.35) | VCAM1GAA | |
| SCHEMBL7523688 | 0.72 | VCAM1 (0.35) | VCAM1GAAALDH1A1MAPT | |
| SCHEMBL7523462 | 0.71 | VCAM1 (0.52) | VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |