Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521009 | 0.87 | VCAM1 (0.37) | CALM1GAAVCAM1KMT2A | |
| SCHEMBL7517609 | 0.86 | VCAM1 (0.45) | CALM1GAAALDH1A1MAPTVCAM1 | |
| SCHEMBL7523700 | 0.86 | NR1H4 (0.35) | GAAVCAM1KMT2AMEN1NR1H4 | |
| SCHEMBL7516554 | 0.84 | GAA (0.34) | GAAMAPTVCAM1KMT2AMEN1 | |
| SCHEMBL7517862 | 0.84 | AKT1 (0.34) | CALM1GAAALDH1A1MAPTHPGD | |
| SCHEMBL7526592 | 0.82 | MEN1 (0.32) | ALDH1A1MAPTHPGDVCAM1KMT2A | |
| SCHEMBL7522270 | 0.74 | GAA (0.37) | GAAVCAM1KMT2AMEN1 | |
| SCHEMBL7518926 | 0.74 | SLC6A9 (0.33) | GAAALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL7527917 | 0.73 | VCAM1 (0.40) | GAAHPGDVCAM1KMT2AMEN1 | |
| SCHEMBL9354087 | 0.72 | VCAM1 (0.45) | GAAVCAM1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |