Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ESRRG | P62508 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PPIB | P23284 | 1/20 | 0.31 |
| ▸ | PPIA | P62937 | 1/20 | 0.31 |
| ▸ | PPID | Q08752 | 1/20 | 0.31 |
| ▸ | PPIG | Q13427 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516554 | 0.86 | GAA (0.34) | NR1H4GAAVCAM1KMT2AMEN1 | |
| SCHEMBL7522609 | 0.86 | CALM1 (0.33) | NR1H4GAAVCAM1KMT2AMEN1 | |
| SCHEMBL7518915 | 0.81 | GAA (0.43) | GAAKMT2AMEN1 | |
| SCHEMBL7520189 | 0.80 | VCAM1 (0.37) | NR1H4CYP19A1CTSLCTSBVCAM1 | |
| SCHEMBL7522270 | 0.76 | GAA (0.37) | GAAVCAM1KMT2AMEN1 | |
| SCHEMBL7527917 | 0.74 | VCAM1 (0.40) | GAAVCAM1KMT2APPIDMEN1 | |
| SCHEMBL9354087 | 0.74 | VCAM1 (0.45) | GAAVCAM1KMT2A | |
| SCHEMBL7521009 | 0.73 | VCAM1 (0.37) | GAAVCAM1KMT2A | |
| SCHEMBL7517609 | 0.73 | VCAM1 (0.45) | GAAVCAM1 | |
| SCHEMBL4324980 | 0.73 | NR1H4 (0.39) | NR1H4CYP19A1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |