Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521976 | 0.86 | ESR1 (0.36) | MAPTALOX12KDM4EHPGDHSD17B10 | |
| SCHEMBL7515172 | 0.84 | TYR (0.40) | MAPTALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL7520582 | 0.82 | ESR1 (0.33) | MAPTHSP90AA1ALOX15ALOX12KDM4E | |
| SCHEMBL27515457 | 0.80 | ESR1 (0.37) | MAPTHSP90AA1ALOX15ALOX12KDM4E | |
| SCHEMBL7529793 | 0.80 | ALOX15 (0.35) | MAPTHSP90AA1ALOX15ALOX12KDM4E | |
| SCHEMBL8441756 | 0.77 | MAPT (0.38) | MAPTALOX15KDM4EHPGDHSD17B10 | |
| SCHEMBL8578127 | 0.77 | GABRA1 (0.39) | MAPTHSP90AA1ALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL7526756 | 0.74 | MAPT (0.36) | MAPTALOX15ALOX12KDM4EHPGD | |
| SCHEMBL7520118 | 0.73 | ESR1 (0.36) | MAPTALOX15ALOX12KDM4EALDH1A1 | |
| SCHEMBL7520561 | 0.70 | HSP90AA1 (0.37) | MAPTHSP90AA1ALOX15HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |