Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | F13A1 | P00488 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA6 | P23280 | 2/20 | 0.48 |
| ▸ | CA5A | P35218 | 2/20 | 0.48 |
| ▸ | THPO | P40225 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.48 |
| ▸ | CASP2 | P42575 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678656 | 1.00 | TDP1 (0.52) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| SCHEMBL5518322 | 0.90 | ALOX15 (0.54) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| SCHEMBL10045100 | 0.89 | TDP1 (0.52) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| SCHEMBL7522951 | 0.88 | ALOX15 (0.56) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| SCHEMBL427900 | 0.88 | TDP1 (0.59) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| Hydrochloric Acid SCHEMBL6114403 | 0.86 | UBE2N (0.58) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| Hydrochloric Acid SCHEMBL28341342 | 0.86 | UBE2N (0.58) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| SCHEMBL323710 | 0.86 | TDP1 (0.61) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| SCHEMBL322792 | 0.84 | ALOX15 (0.54) | TDP1CYP1A2CYP2C19ALOX15MEN1 | |
| SCHEMBL4562189 | 0.84 | PAOX (0.55) | TDP1CYP1A2CYP2C19ALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020045780-A1 | Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment | BERGERON RAYMOND J (US) | 2002-04-18 | — | — | US | disclosed |
| US-6235794-B1 | ANTICANCER AGENT | UNIVERSITY OF FLORIDA | 2001-05-22 | — | — | US | disclosed |
| US-5498522-A | ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | HEALTH RESEARCH, INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0568338-A2 | Methods for the use of spermidine/spermine N'-acetyltransferase as a progonostic indicator and/or a tumor response marker | HEALTH RESEARCH, INC. (US) | 1993-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045780-A1 | Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment | SRM, SLC7A1, CATSPER1 | TDP1 1639/4885CYP1A2 3146/4885CYP2C19 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.