Sugi Predict

Sugi Predict / Compounds / Biphenyl

Biphenyl

Biphenyl

SCHEMBL7519251

Br.c1ccc(-c2ccccc2)cc1.c1ccc(-c2ccccc2)cc1.c1ccc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC6A2 known ✓ P23975 1/20 0.35
▸ KCNN4 O15554 3/20 0.44
▸ ALDH1A1 P00352 4/20 0.41
▸ KIF11 P52732 2/20 0.38
▸ TDP1 Q9NUW8 3/20 0.36
▸ HSD17B10 Q99714 2/20 0.36
▸ CTSD P07339 1/20 0.36
▸ MGLL Q99685 1/20 0.35
▸ TSHR P16473 4/20 0.35
▸ PTGS2 P35354 2/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ ALOX12 P18054 1/20 0.35
▸ PTGS1 P23219 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ HTR2B P41595 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ IDO1 P14902 2/20 0.33
▸ CYP2C9 P11712 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11279906 0.91 KCNN4 (0.52) KCNN4ALDH1A1KIF11TDP1HSD17B10
SCHEMBL18035826 0.76 ALDH1A1 (0.44) KCNN4ALDH1A1KIF11TDP1MAPK1
SCHEMBL874147 0.76 KCNN4 (0.43) KCNN4ALDH1A1KIF11TSHRALOX15
SCHEMBL23112981 0.76 KCNN4 (0.43) KCNN4ALDH1A1KIF11TDP1HSD17B10
SCHEMBL654702 0.72 MAPK13 (0.42) KCNN4ALDH1A1L3MBTL1LMNA
SCHEMBL27675660 0.72 KCNN4 (0.40) KCNN4ALDH1A1KIF11TDP1HSD17B10
SCHEMBL7535593 0.71 KCNN4 (0.39) KCNN4ALDH1A1KIF11TDP1HSD17B10
SCHEMBL9479803 0.71 NPC1 (0.49) ALDH1A1KIF11L3MBTL1CYP2C9LMNA
SCHEMBL11043879 0.70 KCNN4 (0.46) KCNN4ALDH1A1TDP1HSD17B10CTSD
SCHEMBL6929062 0.70 ALDH1A1 (0.43) KCNN4ALDH1A1TDP1HSD17B10CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020057050-A1 Organic light emitting diode devices using aromatic amine compounds with high and tunable glass transition temperatures EMAGIN CORPORATION 2002-05-16 — — US disclosed
WO-2002001653-A2 ORGANIC LIGHT EMITTING DIODE DEVICES USING AROMATIC AMINE COMPOUNDS WITH HIGH AND TUNABLE GLASS TRANSITION TEMPERATURES EMAGIN CORPORATION (US) 2002-01-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020057050-A1 Organic light emitting diode devices using aromatic amine compounds with high and tunable glass transition temperatures DRD4, DRD2, DRD1 SLC6A2 57/4885KCNN4 515/4885ALDH1A1 1300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.