Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7518651 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2213373 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4270106 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7518661 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL27711584 | 0.89 | ALOX15 (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL28123858 | 0.87 | ALOX15 (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL4891196 | 0.87 | ALOX15 (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL17865 | 0.87 | — | — | |
| SCHEMBL156659 | 0.87 | FFAR3 (0.47) | TSHRTP53ALOX15HSD17B10TET2 | |
| Acrylic Acid SCHEMBL28411354 | 0.85 | ALOX15 (0.60) | TSHRTP53ALOX15HSD17B10TET2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487084-B1 | Image forming method and apparatus | CANON KK (JP) | 2002-01-30 | — | — | EP | disclosed |
| US-5864406-A | Method and apparatus for forming halftone images on organic-silver-salt-based printing plates | CANON KABUSHIKI KAISHA (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0487084-A2 | Image forming method and apparatus | CANON KABUSHIKI KAISHA (JP) | 1992-05-27 | — | — | EP | disclosed |