Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7520083 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL7518651 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2213373 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7518661 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL27711584 | 0.89 | ALOX15 (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL28123858 | 0.87 | ALOX15 (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL4891196 | 0.87 | ALOX15 (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL17865 | 0.87 | — | — | |
| SCHEMBL156659 | 0.87 | FFAR3 (0.47) | TSHRTP53ALOX15HSD17B10TET2 | |
| Acrylic Acid SCHEMBL28411354 | 0.85 | ALOX15 (0.60) | TSHRTP53ALOX15HSD17B10TET2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233935-A1 | Methods for Fabrication of Antimicrobial Surfaces | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2009-09-17 | — | — | US | disclosed |
| EP-1945229-A2 | METHODS FOR FABRICATION OF ANTIMICROBIAL SURFACES | Research Foundation of the City University of New York (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2008018890-A2 | METHODS FOR FABRICATION OF ANTIMICROBIAL SURFACES | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233935-A1 | Methods for Fabrication of Antimicrobial Surfaces | ADH1A, ADH1C, HAO2 | TSHR 2444/4885TP53 4117/4885EGLN1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.