Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7520083 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL7518651 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4270106 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7518661 | 1.00 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL27711584 | 0.89 | ALOX15 (0.39) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Crotonic Acid SCHEMBL28123858 | 0.87 | ALOX15 (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL4891196 | 0.87 | ALOX15 (0.38) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL17865 | 0.87 | — | — | |
| SCHEMBL156659 | 0.87 | FFAR3 (0.47) | TSHRTP53ALOX15HSD17B10TET2 | |
| Acrylic Acid SCHEMBL28411354 | 0.85 | ALOX15 (0.60) | TSHRTP53ALOX15HSD17B10TET2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2082082-B1 | MULTI-COMPONENT FIBERS CONTAINING HIGH CHAIN-LENGTH POLYAMIDES | ARKEMA INC (US) | 2011-07-27 | — | — | EP | disclosed |
| US-20100062669-A1 | MULTI-COMPONENT FIBERS CONTAINING HIGH CHAIN-LENGTH POLYAMIDES | ARKEMA INC. (US) | 2010-03-11 | — | — | US | disclosed |
| EP-1562621-B1 | COMPOSITION FOR TREATING ICHTHYOSIS USING ANTITRYPSIN | ARRIVA PROMETIC INC (CA) | 2009-08-19 | — | — | EP | disclosed |
| EP-2082082-A2 | MULTI-COMPONENT FIBERS CONTAINING HIGH CHAIN-LENGTH POLYAMIDES | Arkema Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008060830-A2 | MULTI-COMPONENT FIBERS CONTAINING HIGH CHAIN-LENGTH POLYAMIDES | ARKEMA INC. (US) | 2008-05-22 | — | — | WO | disclosed |
| US-20080095806-A1 | Composition And Method For Treating Inflammatory Diseases Using Protease Inhibitors | PROMETIC BIOSCIENCES, INC. (CA) | 2008-04-24 | — | — | US | disclosed |
| WO-2005117955-A1 | TREATMENT OF ATOPIC DERMATITIS WITH UNGLYCOSYLATED ALPHA ONE-ANTITRYPSIN | ARRIVA PHARMACEUTICALS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| EP-1562621-A1 | COMPOSITION AND METHOD FOR TREATING INFLAMMATORY DISEASES USING PROTEASE INHIBITORS | Arriva-Prometic Inc. (CA) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004045634-A1 | COMPOSITION AND METHOD FOR TREATING INFLAMMATORY DISEASES USING PROTEASE INHIBITORS | ARRIVA-PROMETIC INC. (CA) | 2004-06-03 | — | — | WO | disclosed |