Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28445561 | 0.79 | CYP2A6 (0.41) | CYP2B6SMN1; SMN2RAB9ATP53LMNA | |
| SCHEMBL28058505 | 0.79 | CYP2B6 (0.33) | KMT2ACYP2B6 | |
| SCHEMBL28451959 | 0.78 | HTR2C (0.41) | KMT2ACYP2B6SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL11192919 | 0.76 | CYP2B6 (0.42) | CYP2B6CA9CA1CYP1A1CYP1A2 | |
| SCHEMBL12043463 | 0.76 | CYP2B6 (0.42) | CYP2B6CA9CA1CA2CA7 | |
| SCHEMBL3554338 | 0.74 | HTR7 (0.37) | MAPTCA12CA9CA1CA2 | |
| SCHEMBL28445449 | 0.74 | CA12 (0.34) | KMT2ACYP2B6MAPTCA12CA9 | |
| SCHEMBL9112587 | 0.73 | CYP2B6 (0.39) | KMT2ACYP2B6SMN1; SMN2NPC1MAPT | |
| SCHEMBL9536321 | 0.73 | ALDH1A1 (0.49) | KMT2ACYP2B6SMN1; SMN2MAPTTP53 | |
| SCHEMBL28080049 | 0.72 | NFE2L2 (0.30) | NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62063582-A | — | — | None | — | — | JP | disclosed |
| CN-111417396-A | Methods of treating cancer with small molecule NF-kB inhibitors | 免疫目标公司 | 2020-07-14 | — | — | CN | disclosed |
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |
| EP-0161218-B1 | BENZO-(PYRANO AND THIOPYRANO)PYRIDINES | CIBA-GEIGY AG (CH) | 1991-06-26 | — | — | EP | disclosed |
| US-4721787-A | CONDENSATION, REDUCTION, DEHYDRATION | CIBA-GEIGY CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |
| JP-S6263582-A | PRODUCTION OF 3,4-DIHYDRO-3-HYDROXY-8-METHOXY-2H-1-BENZOPYRAN | KOWA CO | 1987-03-20 | — | — | JP | disclosed |
| US-4604397-A | Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS agents | CIBA-GEIGY CORPORATION (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0161218-A2 | Benzo-(pyrano and thiopyrano)pyridines | CIBA-GEIGY AG (CH) | 1985-11-13 | — | — | EP | disclosed |