Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 14/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521719 | 0.81 | ALOX15 (0.42) | — | |
| SCHEMBL7523700 | 0.80 | NR1H4 (0.35) | VCAM1NR1H4CYP19A1CTSLCTSB | |
| SCHEMBL7524487 | 0.77 | NR1H4 (0.40) | NR1H4 | |
| SCHEMBL7513863 | 0.75 | VCAM1 (0.57) | VCAM1 | |
| SCHEMBL7525083 | 0.73 | VCAM1 (0.52) | VCAM1 | |
| SCHEMBL7523485 | 0.72 | POLB (0.40) | CYP19A1CTSLCTSB | |
| SCHEMBL4324980 | 0.72 | NR1H4 (0.39) | VCAM1NR1H4CYP19A1 | |
| SCHEMBL7523469 | 0.69 | ALOX15 (0.40) | NR1H4 | |
| SCHEMBL5692124 | 0.68 | HPN (0.45) | VCAM1 | |
| SCHEMBL7523672 | 0.68 | BACE1 (0.39) | VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |