Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525047 | 0.79 | TSHR (0.34) | HTT | |
| SCHEMBL7520189 | 0.72 | VCAM1 (0.37) | CYP19A1CTSLCTSB | |
| SCHEMBL7521661 | 0.66 | KDM4E (0.31) | ALDH1A1 | |
| SCHEMBL1469593 | 0.63 | ACHE (0.59) | POLBHTTCYP19A1ACHEALDH1A1 | |
| SCHEMBL4520980 | 0.63 | ACHE (0.46) | POLBHTTCYP19A1ACHEALDH1A1 | |
| SCHEMBL2910532 | 0.62 | POLB (0.62) | POLBHTTPTPN1ACHEALDH1A1 | |
| SCHEMBL7519795 | 0.62 | HTT (0.49) | POLBHTTPTPN1PTGS2ALDH1A1 | |
| SCHEMBL7523700 | 0.61 | NR1H4 (0.35) | CYP19A1CTSLCTSB | |
| SCHEMBL7520501 | 0.61 | HTT (0.48) | POLBHTTPTPN1ACHEPTGS2 | |
| SCHEMBL15642113 | 0.61 | POLB (0.65) | POLBHTTPTPN1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |