SCHEMBL7520344

SCHEMBL7520344

C[C@@H]1C(=O)c2ccccc2O[C@@]1(O)c1ccc(Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.45
KDR P35968 1/20 0.45
CHRNA1 P02708 2/20 0.40
CHRNG P07510 2/20 0.40
CHRNB1 P11230 2/20 0.40
CHRNB2 P17787 2/20 0.40
SLC6A2 P23975 2/20 0.40
CHRNB4 P30926 2/20 0.40
SLC6A4 P31645 2/20 0.40
CHRNA3 P32297 2/20 0.40
CHRNA4 P43681 2/20 0.40
SLC6A3 Q01959 2/20 0.40
CHRND Q07001 2/20 0.40
MAOB P27338 1/20 0.39
CYP3A4 P08684 2/20 0.39
ALOX15 P16050 1/20 0.39
MDM2 Q00987 4/20 0.38
RAB9A P51151 1/20 0.37
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3306471 0.87 CYP19A1 (0.43) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL7521676 0.87 MAPT (0.43) CYP3A4ALOX15RAB9AALDH1A1MAPT
SCHEMBL2337166 0.87 CYP19A1 (0.43) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL7527043 0.85 CHRNA1 (0.45) RETKDRCHRNA1CHRNGCHRNB1
SCHEMBL8484519 0.85 CYP19A1 (0.47) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL7523465 0.84 MAP3K14 (0.39) RETKDRCHRNA1CHRNGCHRNB1
SCHEMBL7522670 0.84 CYP19A1 (0.44) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL7516218 0.84 MEN1 (0.40) MAOBCYP3A4ALOX15RAB9AALDH1A1
SCHEMBL7519643 0.84 MAP3K14 (0.39) RETKDRCHRNA1CHRNGCHRNB1
SCHEMBL7530287 0.83 OPRD1 (0.37) CYP3A4ALOX15MDM2ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0743311-B1 FLAVANONOL DERIVATIVES AND HAIR NOURISHMENT AND GROWTH STIMULANT COMPOSITION CONTAINING THE SAME KAO CORP (JP) 2002-02-13 EP disclosed
US-5876703-A CELL DIFFERENTIATION OF HAIR MATRIX CELLS KAO CORPORATION (JP) 1999-03-02 US disclosed
US-5702691-A Flavanonol derivatives and hair-nourishing, hair growing compositions containing the derivatives KAO CORPORATION (JP) 1997-12-30 US disclosed
EP-0743311-A1 FLAVANONOL DERIVATIVES AND HAIR NOURISHMENT AND GROWTH STIMULANT COMPOSITION CONTAINING THE SAME Kao Corporation (JP) 1996-11-20 EP disclosed