SCHEMBL3306471

SCHEMBL3306471

Cc1ccc([C@]2(O)Oc3ccccc3C(=O)[C@H]2C)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 3/20 0.43
CHRNA1 P02708 1/20 0.38
CHRNG P07510 1/20 0.38
CHRNB1 P11230 1/20 0.38
CHRNB2 P17787 1/20 0.38
SLC6A2 P23975 1/20 0.38
CHRNB4 P30926 1/20 0.38
CHRNA3 P32297 1/20 0.38
CHRNA4 P43681 1/20 0.38
SLC6A3 Q01959 1/20 0.38
CHRND Q07001 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 4/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
CYP3A4 P08684 1/20 0.37
ALOX15 P16050 1/20 0.37
MAOB P27338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2337166 1.00 CYP19A1 (0.43) CYP19A1CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL7521676 0.89 MAPT (0.43) MEN1KMT2AMAPTCYP2C19CYP3A4
SCHEMBL7520344 0.87 RET (0.45) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL8484519 0.86 CYP19A1 (0.47) CYP19A1CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL7519608 0.86 CYP19A1 (0.39) CYP19A1CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL7516218 0.85 MEN1 (0.40) MEN1KMT2AMAPTCYP3A4ALOX15
SCHEMBL7530287 0.84 OPRD1 (0.37) CYP3A4ALOX15OPRD1MDM2
SCHEMBL7520906 0.84 KDM4E (0.39) KMT2AMAPTCYP2C19CYP3A4ALOX15
SCHEMBL7520904 0.83 CYP19A1 (0.45) CYP19A1CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL7526818 0.83 CYP19A1 (0.45) CYP19A1CHRNA1CHRNGCHRNB1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2742930-B1 COSMETIC EMULSION FOR EYEBROWS OR EYELASHES KAO CORP (JP) 2018-10-10 EP claimed
EP-2742930-A1 COSMETIC EMULSION FOR EYEBROWS OR EYELASHES Kao Corporation (JP) 2014-06-18 EP claimed
JP-10152486-A None JP disclosed
JP-8157464-A None JP disclosed
EP-2742930-B1 COSMETIC EMULSION FOR EYEBROWS OR EYELASHES KAO CORP (JP) 2018-10-10 EP disclosed
EP-2119428-B1 Use and method for reducing hair frizz KAO CORP (JP) 2016-11-02 EP disclosed
EP-2742930-A1 COSMETIC EMULSION FOR EYEBROWS OR EYELASHES Kao Corporation (JP) 2014-06-18 EP disclosed
US-20130125915-A1 HAIR FRIZZINESS REDUCING AGENT KAO CORPORATION (JP) 2013-05-23 US disclosed
US-20100092415-A1 HAIR FRIZZINESS REDUCING AGENT KAO CORPORATION (JP) 2010-04-15 US disclosed
EP-2119428-A1 AGENT FOR IMPROVING HAIR WAVING Kao Corporation (JP) 2009-11-18 EP disclosed
EP-0743311-B1 FLAVANONOL DERIVATIVES AND HAIR NOURISHMENT AND GROWTH STIMULANT COMPOSITION CONTAINING THE SAME KAO CORP (JP) 2002-02-13 EP disclosed
US-5876703-A CELL DIFFERENTIATION OF HAIR MATRIX CELLS KAO CORPORATION (JP) 1999-03-02 US disclosed
JP-H10152486-A PRODUCTION OF 3-ALKYLFLAVANONOL DERIVATIVE KAO CORP 1998-06-09 JP disclosed
US-5702691-A Flavanonol derivatives and hair-nourishing, hair growing compositions containing the derivatives KAO CORPORATION (JP) 1997-12-30 US disclosed
EP-0743311-A1 FLAVANONOL DERIVATIVES AND HAIR NOURISHMENT AND GROWTH STIMULANT COMPOSITION CONTAINING THE SAME Kao Corporation (JP) 1996-11-20 EP disclosed
JP-H08157464-A FLAVANONOL DERIVATIVE KAO CORP 1996-06-18 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130125915-A1 HAIR FRIZZINESS REDUCING AGENT FZD7, SFRP1, FLNA CYP19A1 3966/4885CHRNA1 4105/4885CHRNG 4428/4885
US-20100092415-A1 HAIR FRIZZINESS REDUCING AGENT FZD7, SFRP1, FLNA CYP19A1 3966/4885CHRNA1 4105/4885CHRNG 4428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.