Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521667 | 0.83 | ALOX5 (0.38) | TRPA1ATMMAPTKDM4EALDH1A1 | |
| SCHEMBL8444610 | 0.82 | GAA (0.43) | TRPA1ATMMAPTMAPK1HSD17B10 | |
| SCHEMBL8377921 | 0.81 | TRPA1 (0.42) | TRPA1ATMMAPTKDM4EMAPK1 | |
| SCHEMBL7518276 | 0.80 | TRPA1 (0.37) | TRPA1ATMMAPTKDM4EMAPK1 | |
| SCHEMBL7517858 | 0.78 | ALOX15 (0.43) | TRPA1ATMMAPTKDM4EMAPK1 | |
| SCHEMBL8387017 | 0.77 | ALDH1A1 (0.38) | TRPA1ATMALDH1A1HTR1B | |
| SCHEMBL7519189 | 0.72 | TRPA1 (0.38) | TRPA1ATMMAPTNPSR1KDM4E | |
| SCHEMBL18831436 | 0.72 | SLC22A12 (0.52) | TRPA1ATMMAPTNPSR1KDM4E | |
| SCHEMBL7515890 | 0.72 | ALDH1A1 (0.41) | TRPA1ATMMAPTNPSR1HSD17B10 | |
| SCHEMBL7526769 | 0.71 | TRPA1 (0.37) | TRPA1ATMMAPTNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |