Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.34 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521636 | 0.84 | NR1I2 (0.33) | ALDH1A1ALOX15 | |
| SCHEMBL7520207 | 0.80 | ALDH1A1 (0.39) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL8440795 | 0.79 | GABRA1 (0.41) | CYP1A2CYP3A4TSHRHIF1A | |
| SCHEMBL7517241 | 0.78 | GABRA1 (0.35) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL7521936 | 0.76 | ALDH1A1 (0.35) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL7520622 | 0.74 | FAAH (0.34) | CYP1A2CYP3A4TSHRHIF1A | |
| SCHEMBL7518999 | 0.74 | ALDH1A1 (0.33) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL7521517 | 0.73 | ALOX15 (0.34) | ALDH1A1ALOX15SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL8439852 | 0.64 | ALDH1A1 (0.41) | ALDH1A1TSHRTDP1 | |
| SCHEMBL7520590 | 0.64 | GABRA1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |