SCHEMBL7863483

SCHEMBL7863483

C[Si](C)(CCl)c1ccc(F)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.36
RAB9A P51151 4/20 0.33
NPC1 O15118 3/20 0.33
NR1H2 P55055 5/20 0.32
NR1H3 Q13133 5/20 0.32
TSHR P16473 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
TP53 P04637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
IDO1 P14902 1/20 0.32
LOXL2 Q9Y4K0 1/20 0.32
USP2 O75604 1/20 0.31
POLB P06746 1/20 0.31
TAAR1 Q96RJ0 3/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
SLC2A1 P11166 1/20 0.31
CYP19A1 P11511 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9559638 0.81 TAAR1 (0.31) ACHENR1H2NR1H3TAAR1
SCHEMBL9358733 0.81 ACHE (0.36) ACHERAB9ANPC1TSHRSMN1; SMN2
SCHEMBL9656709 0.79 NR1H2 (0.41) ACHENR1H2NR1H3SLC2A1
SCHEMBL8755288 0.78 ACHE (0.40) ACHERAB9ANPC1SMN1; SMN2TP53
SCHEMBL8983871 0.78 LMNA (0.40) IDO1TAAR1LMNA
SCHEMBL27352036 0.78 ACHE (0.38) ACHERAB9ANPC1NR1H2NR1H3
SCHEMBL7523329 0.77 NR1H2 (0.42) NR1H2NR1H3TSHRIDO1TAAR1
SCHEMBL2006055 0.76 LOXL2 (0.42) ACHERAB9ANPC1NR1H2NR1H3
SCHEMBL8757205 0.76 CYP2A6 (0.38) IDO1TAAR1CYP19A1CYP11B1CYP11B2
SCHEMBL9559622 0.76 TP53 (0.39) RAB9ANPC1TSHRSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6313344-B1 PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-11-06 US disclosed
EP-0984923-A1 O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES Novartis AG (CH) 2000-03-15 EP disclosed
WO-1998054125-A1 O-BENZYL OXIME ETHERS AND THEIR USE AS PESTICIDES NOVARTIS AG (CH) 1998-12-03 WO disclosed
US-5235061-A 2,4-disilaalkanes; agriculture KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1993-08-10 US disclosed
EP-0472304-A2 Pharmaceutical compositions containing therapeutically active organosilane derivatives and process for preparing same Richter Gedeon Vegyészeti Gyár R.T. (HU) 1992-02-26 EP disclosed