Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303871 | 0.75 | NR1H2 (0.50) | NR1H2ESR2LTA4HCA2MEN1 | |
| SCHEMBL27333675 | 0.73 | CA1 (0.41) | NR1H2ESR2CA2CA12CA1 | |
| SCHEMBL19865715 | 0.71 | NR1H2 (0.46) | NR1H2ESR2LTA4HCA2MEN1 | |
| SCHEMBL583468 | 0.69 | NR1H2 (0.55) | NR1H2ESR2LTA4HCA2MEN1 | |
| SCHEMBL6362994 | 0.68 | LMNA (0.42) | NR1H2CA2MEN1KMT2AALDH1A1 | |
| SCHEMBL9839146 | 0.68 | NR1H2 (0.38) | NR1H2ESR2MEN1KMT2AALDH1A1 | |
| Methoxymethane SCHEMBL10979307 | 0.67 | NR1H2 (0.78) | NR1H2ESR2LTA4HCA2MEN1 | |
| SCHEMBL1923910 | 0.67 | LTA4H (0.54) | ESR2LTA4HMEN1KMT2ALMNA | |
| SCHEMBL537145 | 0.67 | LMNA (0.45) | NR1H2LTA4HCA2ALDH1A1LMNA | |
| Hydroquinone SCHEMBL11136724 | 0.66 | LTA4H (0.52) | ESR2LTA4HCA2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192178-A2 | RUFOMYCINS AND DERIVATIVES THEREOF USEFUL AS INHIBITORS OF MULTI-DRUG RESISTANCE ASSOCIATED PROTEIN-1 (MRP-1) | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | claimed |
| WO-2000078795-A2 | RUFOMYCINS AND DERIVATIVES THEREOF USEFUL AS INHIBITORS OF MULTI-DRUG RESISTANCE ASSOCIATED PROTEIN-1 (MRP-1) | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | claimed |