Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520161 | 0.82 | KIF11 (0.52) | KIF11MAPTDHODHAKR1C3 | |
| SCHEMBL7528545 | 0.78 | KDM4E (0.58) | KMT2AMEN1MAPTCA1KDM4E | |
| SCHEMBL7520380 | 0.78 | MT-CO2 (0.51) | KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7518230 | 0.78 | KDM4E (0.40) | KMT2AMEN1MAPTCA1CA2 | |
| SCHEMBL7517596 | 0.78 | ALDH1A1 (0.54) | KMT2AMEN1MAPTCA1KDM4E | |
| SCHEMBL3214101 | 0.71 | BACE1 (0.42) | KIF11 | |
| SCHEMBL7557829 | 0.71 | KMT2A (0.43) | KIF11EPHX2KMT2AMEN1MAPT | |
| SCHEMBL1921455 | 0.70 | EPHX2 (0.56) | KIF11EPHX2KMT2AMEN1CA1 | |
| SCHEMBL394422 | 0.70 | EPHX2 (0.56) | KIF11EPHX2KMT2AMEN1CA1 | |
| SCHEMBL7526669 | 0.68 | KMT2A (0.60) | EPHX2KMT2AMEN1MAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |