Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520380 | 0.82 | MT-CO2 (0.51) | KDM4ESMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL7518230 | 0.82 | KDM4E (0.40) | KDM4ESMN1; SMN2LMNAALDH1A1RAB9A | |
| SCHEMBL7517596 | 0.81 | ALDH1A1 (0.54) | KDM4ESMN1; SMN2TDP1LMNAPOLB | |
| SCHEMBL7517550 | 0.81 | MAPT (0.50) | KDM4ESMN1; SMN2TDP1LMNAPOLB | |
| SCHEMBL7518501 | 0.79 | ALDH1A1 (0.46) | SMN1; SMN2TDP1LMNAPOLBALDH1A1 | |
| SCHEMBL7524044 | 0.78 | KIF11 (0.40) | KDM4EMAPTMEN1KMT2ACA1 | |
| SCHEMBL7524238 | 0.78 | RAPGEF4 (0.46) | KDM4ESMN1; SMN2TDP1POLBALDH1A1 | |
| SCHEMBL7517906 | 0.72 | KMT2A (0.38) | KDM4EPOLBALDH1A1RAB9ANPC1 | |
| SCHEMBL7515459 | 0.70 | IDO1 (0.43) | ALDH1A1EGFRCA1RAPGEF4 | |
| SCHEMBL13492165 | 0.68 | PTGS1 (0.41) | ALDH1A1HPGDKMT2ACA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |