Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.54 |
| ▸ | XBP1 | P17861 | 3/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745202 | 0.88 | NPC1 (0.61) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL1750846 | 0.76 | ALDH1A1 (0.50) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL4740875 | 0.73 | RAB9A (0.67) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL4187625 | 0.71 | SMN1; SMN2 (0.71) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL4191812 | 0.71 | RAB9A (0.60) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL4743412 | 0.70 | RAB9A (1.00) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL6370511 | 0.70 | NPC1 (0.58) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL1749910 | 0.68 | RAB9A (0.60) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL4191587 | 0.68 | NPC1 (0.69) | NPC1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL4184776 | 0.68 | ALDH1A1 (0.56) | NPC1RAB9AALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020013318-A1 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | BLACK LAWRENCE A (US) | 2002-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013318-A1 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | PTGS1, PTGIS, PTGS2 | NPC1 4230/4885RAB9A 4413/4885ALDH1A1 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.