Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7530442 | 0.86 | KMT2A (0.41) | KDM4EGALR3MAPTHTTSMN1; SMN2 | |
| SCHEMBL7531783 | 0.83 | MAPT (0.38) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6281303 | 0.80 | PDE4A (0.43) | CA12CA2CA9PDE4APDE4B | |
| SCHEMBL7532632 | 0.74 | RAPGEF4 (0.37) | GALR3MAPTHTTSMN1; SMN2GAA | |
| SCHEMBL7532592 | 0.72 | ADRA2C (0.39) | KDM4EADRA2CGAANMT1POLB | |
| SCHEMBL7531156 | 0.71 | NMT1 (0.41) | KDM4EMAPTHTTSMN1; SMN2PLK1 | |
| SCHEMBL7531677 | 0.71 | SMN1; SMN2 (0.40) | KDM4EMAPTHTTSMN1; SMN2GAA | |
| SCHEMBL7527986 | 0.70 | NUDT1 (0.36) | KDM4E | |
| SCHEMBL7533638 | 0.69 | — | — | |
| SCHEMBL1798141 | 0.69 | MAPT (0.49) | CA12CA2CA9PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020032198-A1 | Diaminopyrazoles | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-14 | — | — | US | claimed |
| US-6319941-B1 | TREATMENT OF SMOOTH MUSCLE SPASTICITY OR EXCESS MUSCLE CONTRACTION SUCH AS URGE URINARY INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-20 | — | — | US | claimed |
| US-6458823-B1 | 4,5-DIAMINO DERIVATIVES OF (1H)- PYRAZOLES AND THEIR USE IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, WHICH INCLUDE, URINARY INCONTINENCE, HYPERTENSION, ASTHAMA, PREMATURE LABOR, IRRITABLE BOWL SYNDROM | WYETH | 2002-10-01 | — | — | US | disclosed |
| US-20020032198-A1 | Diaminopyrazoles | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-14 | — | — | US | disclosed |
| US-6319941-B1 | TREATMENT OF SMOOTH MUSCLE SPASTICITY OR EXCESS MUSCLE CONTRACTION SUCH AS URGE URINARY INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-20 | — | — | US | disclosed |
| US-6313149-B1 | Diaminopyrazoles | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-06 | — | — | US | disclosed |
| US-6172222-B1 | Diaminopyrazoles | AMERICAN HOME PRODUCTS CORPORATION | 2001-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032198-A1 | Diaminopyrazoles | ODC1, AOC1, CLIC1 | CA12 2030/4885CA2 247/4885CA9 1749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.