Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.50 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.50 |
| ▸ | F10 | P00742 | 2/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 5/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | C1S | P09871 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527652 | 0.82 | MGLL (0.45) | ST14F10F2MGLLITGB3 | |
| SCHEMBL537872 | 0.81 | PRSS1 (0.53) | PRSS1PRSS2PRSS3ST14F10 | |
| Fluoride SCHEMBL8499766 | 0.80 | PRSS1 (0.52) | PRSS1PRSS2PRSS3ST14F10 | |
| Hydrochloric Acid SCHEMBL1071756 | 0.80 | PRSS1 (0.52) | PRSS1PRSS2PRSS3ST14F10 | |
| SCHEMBL9030764 | 0.76 | MRGPRX1 (0.45) | PRSS1PRSS2PRSS3ST14F10 | |
| SCHEMBL9031768 | 0.74 | KMT2A (0.57) | ST14ITGB3ITGA2BPLAULMNA | |
| SCHEMBL29001419 | 0.74 | MEN1 (0.49) | MGLLLMNA | |
| SCHEMBL20610488 | 0.72 | PRSS1 (0.68) | PRSS1PRSS2PRSS3ST14F10 | |
| SCHEMBL7815090 | 0.72 | F10 (0.68) | PRSS1PRSS2PRSS3ST14F10 | |
| SCHEMBL29001390 | 0.72 | MGLL (0.48) | LOXL2F2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623146-B1 | COMPOSITIONS AND METHODS FOR INHIBITING BETA-PROTEIN FUNCTION | HARVARD COLLEGE (US) | 2002-04-17 | — | — | EP | disclosed |
| US-5506097-A | CONTACTING ALZHEIMER AMYLOID BETA-PROTEIN WITH EBELACTONE A OR PARA-AMIDINOPHENYLMETHANESULFONYL FLUORIDE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0623146-A1 | COMPOUNDS AND METHODS FOR INHIBITING $g(b)-PROTEIN FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993015112-A2 | COMPOUNDS AND METHODS FOR INHIBITING β-PROTEIN FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1993-08-05 | — | — | WO | disclosed |