Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.51 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21725666 | 0.87 | PDE2A (0.54) | PDE2ACES2KDM4EHPGDALDH1A1 | |
| SCHEMBL14054398 | 0.84 | GSK3B (0.50) | PDE2ACES2GSK3BKDM4EHPGD | |
| SCHEMBL311471 | 0.79 | PDE2A (0.45) | PDE2ACES2GSK3BKDM4EHPGD | |
| SCHEMBL6495907 | 0.78 | PDE2A (0.50) | PDE2ACES2KDM4EHPGDALDH1A1 | |
| SCHEMBL30482175 | 0.78 | PDE2A (0.50) | PDE2ACES2KDM4EHPGDALDH1A1 | |
| SCHEMBL1922201 | 0.78 | SMN1; SMN2 (0.55) | KDM4EALDH1A1HSD17B10GAAMAPT | |
| SCHEMBL8393015 | 0.77 | HPGD (0.45) | HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1922910 | 0.77 | MAPK1 (0.46) | HPGDALDH1A1MAPT | |
| SCHEMBL1818435 | 0.76 | KDM4E (0.62) | PDE2ACES2KDM4EHPGDALDH1A1 | |
| SCHEMBL1455625 | 0.76 | CES2 (0.52) | PDE2ACES2KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020137740-A1 | Aminothiazole derivatives, process for preparing them and pharmaceutical compositions containing them | FONTAINE EVELYNE (FR) | 2002-09-26 | — | — | US | disclosed |
| EP-0934290-B1 | AMINOTHIAZOLE DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2002-04-17 | — | — | EP | disclosed |
| US-6344470-B1 | Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-02-05 | — | — | US | disclosed |
| EP-0934290-A1 | AMINOTHIAZOLE DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI (FR) | 1999-08-11 | — | — | EP | disclosed |
| US-5880135-A | ANTAGONIST ACTIVITY WITH RESPECT TO CORTICOTROPIN RELEASING HORMONE | SANOFI (FR) | 1999-03-09 | — | — | US | disclosed |
| WO-1998015543-A1 | AMINOTHIAZOLE DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI (FR) | 1998-04-16 | — | — | WO | disclosed |
| EP-0833822-A1 | 4-PHENYLAMINOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000868-A1 | 4-PHENYLAMINOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1997-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137740-A1 | Aminothiazole derivatives, process for preparing them and pharmaceutical compositions containing them | CRHR1, ADRA1D, ADRB1 | PDE2A 1565/4885CES2 2531/4885GSK3B 3884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.