Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 3/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353356 | 0.83 | COMT (0.47) | IDO1TDO2KDM4EALDH1A1MEN1 | |
| SCHEMBL8350677 | 0.83 | ALDH1A1 (0.47) | IDO1TDO2KDM4EPTGDR2POLB | |
| SCHEMBL6008193 | 0.78 | PTGS2 (0.44) | IDO1TDO2KDM4EALDH1A1CDC7 | |
| SCHEMBL9768642 | 0.75 | ALDH1A1 (0.62) | KDM4EPTGDR2POLBALDH1A1ALOX5 | |
| SCHEMBL7808047 | 0.74 | IDO1 (0.79) | IDO1TDO2KDM4EPTGDR2POLB | |
| SCHEMBL16011062 | 0.73 | ALOX5 (0.50) | KDM4EPTGDR2POLBALDH1A1ALOX5 | |
| SCHEMBL22732884 | 0.72 | IDO1 (0.63) | IDO1TDO2KDM4EPTGDR2POLB | |
| SCHEMBL12854108 | 0.70 | IDO1 (0.49) | IDO1TDO2KDM4EPTGDR2POLB | |
| SCHEMBL14832763 | 0.68 | ALOX5 (0.41) | IDO1TDO2KDM4EPTGDR2POLB | |
| SCHEMBL21670773 | 0.68 | PTGS2 (0.56) | KDM4EPTGDR2ALDH1A1ALOX5CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022122-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2002-03-21 | — | — | WO | claimed |
| WO-2002022122-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2002-03-21 | — | — | WO | disclosed |
| WO-1999032115-A1 | MODULATORS OF RYANODINE RECEPTORS COMPRISING 2-(ARYL)-4,7-DIOXOBENZOTHIAZOLES AND ANALOGUES THEREOF | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. (US) | 1999-07-01 | — | — | WO | disclosed |