SCHEMBL8350677

SCHEMBL8350677

O=C1C=CC(=O)c2sc(-c3ccc(Cl)cc3)nc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
KMT2A Q03164 2/20 0.47
PTGS2 P35354 1/20 0.46
NOTUM Q6P988 2/20 0.44
KDM4E B2RXH2 4/20 0.43
PTGDR2 Q9Y5Y4 4/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
HPGD P15428 1/20 0.43
CYP2C19 P33261 1/20 0.43
ALOX5 P09917 1/20 0.42
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
POLB P06746 1/20 0.42
APEX1 P27695 1/20 0.40
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8353356 0.83 COMT (0.47) ALDH1A1KMT2AKDM4EALOX5RAB9A
SCHEMBL7532432 0.83 IDO1 (0.46) ALDH1A1KMT2APTGS2KDM4EPTGDR2
SCHEMBL11460695 0.71 KDM4E (0.58) ALDH1A1KMT2APTGS2KDM4EPTGDR2
SCHEMBL11462189 0.71 KDM4E (0.58) ALDH1A1KMT2APTGS2KDM4EPTGDR2
SCHEMBL11284205 0.71 KDM4E (0.58) ALDH1A1KMT2APTGS2KDM4EPTGDR2
SCHEMBL6008193 0.69 PTGS2 (0.44) ALDH1A1PTGS2KDM4ERAB9ANPC1
SCHEMBL11460720 0.68 RAB9A (0.58) ALDH1A1KMT2APTGS2KDM4EALOX5
SCHEMBL11275235 0.68 ALOX5 (0.74) ALDH1A1KMT2APTGS2KDM4EPTGDR2
SCHEMBL25028283 0.68 ALDH1A1 (0.52) ALDH1A1KMT2ANOTUMKDM4EPTGDR2
SCHEMBL25675898 0.67 APEX1 (0.46) ALDH1A1KMT2APTGS2NOTUMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999032115-A1 MODULATORS OF RYANODINE RECEPTORS COMPRISING 2-(ARYL)-4,7-DIOXOBENZOTHIAZOLES AND ANALOGUES THEREOF ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. (US) 1999-07-01 WO disclosed