Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532707 | 1.00 | NR1D1 (0.55) | NR1D1ACEPOLBITGB1ITGA5 | |
| SCHEMBL382552 | 0.82 | ACE (0.52) | NR1D1ACEPOLBALDH1A1TDP1 | |
| SCHEMBL14747164 | 0.82 | NR1D1 (0.63) | NR1D1ACE | |
| SCHEMBL14747166 | 0.82 | NR1D1 (0.63) | NR1D1ACE | |
| SCHEMBL8495772 | 0.79 | LMNA (0.61) | ACEPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL8722562 | 0.77 | POLB (0.65) | NR1D1ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL4113622 | 0.77 | ACE (0.66) | ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL8908771 | 0.77 | ACE (0.61) | ACEPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL3840630 | 0.77 | ACE (0.61) | ACEPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL4573235 | 0.77 | ACE (0.61) | ACEPOLBALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045844-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1045844-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5932590-A | PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION | MERCK & CO., INC. (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1999028314-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |