Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | GFRA2 | O00451 | 1/20 | 0.36 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | FADS1 | O60427 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533622 | 0.72 | GPR84 (0.42) | IDO1GFRA2GFRA3GPR84 | |
| SCHEMBL7425979 | 0.72 | NPC1 (0.43) | IDO1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7258599 | 0.72 | IDO1 (0.63) | IDO1GPR84 | |
| SCHEMBL30728437 | 0.69 | GPR84 (0.57) | IDO1HTR1ADRD2GPR84FFAR1 | |
| SCHEMBL14461584 | 0.69 | IDO1 (0.59) | IDO1HTR1ADRD2GPR84FFAR1 | |
| SCHEMBL4568818 | 0.69 | SIRT2 (0.52) | — | |
| SCHEMBL2090211 | 0.66 | MTNR1B (0.62) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL12963096 | 0.66 | SYK (0.49) | KMT2AALDH1A1MAPTF2 | |
| SCHEMBL9626216 | 0.66 | IDO1 (0.51) | IDO1HTR1ADRD2GPR84CYP2D6 | |
| SCHEMBL25959895 | 0.65 | HIF1A (0.41) | MAPTHTTCYP1A2CYP2D6F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |