Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637327 | 0.76 | FFAR1 (0.43) | PDE4APDE4BPDE4CPDE4DNOX1 | |
| SCHEMBL3821707 | 0.74 | MAPT (0.53) | MEN1CYP1A2KMT2AKDM4EALDH1A1 | |
| SCHEMBL4637286 | 0.74 | ALDH1A1 (0.51) | PDE4APDE4BPDE4CPDE4DNOX1 | |
| SCHEMBL7425987 | 0.74 | SMPD1 (0.47) | SMPD1IDO1KDM4E | |
| SCHEMBL7533615 | 0.72 | IDO1 (0.38) | DRD2DRD4DRD3HTR1AMEN1 | |
| SCHEMBL8707317 | 0.70 | NR1H3 (0.51) | PDE4APDE4BPDE4CPDE4DNOX1 | |
| SCHEMBL15136802 | 0.70 | PDE4A (0.60) | NPC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4637258 | 0.70 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12320927 | 0.69 | AR (0.47) | PDE4APDE4BPDE4CPDE4DNOX1 | |
| SCHEMBL7424982 | 0.68 | ALDH1A1 (0.51) | PDE4APDE4BPDE4CPDE4DDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |