Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755809 | 0.87 | KCNH2 (0.46) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL14516176 | 0.87 | KCNH2 (0.46) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL22454446 | 0.81 | CYP2D6 (0.40) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL17750791 | 0.81 | CYP2D6 (0.40) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL14987836 | 0.81 | KCNH2 (0.41) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL16751400 | 0.81 | KCNH2 (0.45) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL669655 | 0.80 | KCNH2 (0.38) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL14974361 | 0.80 | KCNH2 (0.38) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL669373 | 0.80 | KCNH2 (0.38) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL14984858 | 0.80 | KCNH2 (0.38) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160102047-A1 | SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHOD AND THE USE THEREOF | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2016-04-14 | — | — | US | disclosed |
| US-9249084-B2 | Substituted n-pentanamide compounds, preparation method and the use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-02-02 | — | — | US | disclosed |
| US-20140046074-A1 | Substituted n-pentanamide compounds, preparation method and the use thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-02-13 | — | — | US | disclosed |
| US-8440863-B2 | Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-14 | — | — | US | disclosed |
| US-8440863-B2 | Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-14 | — | — | US | disclosed |
| US-20120142970-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2 TRIMETHYLPENTANAMINE | FILLIERS WALTER FERDINAND MARIA (BE) | 2012-06-07 | — | — | US | disclosed |
| US-20120142970-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2 TRIMETHYLPENTANAMINE | FILLIERS WALTER FERDINAND MARIA (BE) | 2012-06-07 | — | — | US | disclosed |
| US-8138376-B2 | Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine | JANSSEN PHARMACEUTICA, NV (BE) | 2012-03-20 | — | — | US | disclosed |
| US-8138376-B2 | Preparation of (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentanamine | JANSSEN PHARMACEUTICA, NV (BE) | 2012-03-20 | — | — | US | disclosed |
| US-20090312578-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE | JANSSEN PHARMACEUTICA NA (BE) | 2009-12-17 | — | — | US | disclosed |
| US-20090312578-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE | JANSSEN PHARMACEUTICA NA (BE) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102047-A1 | SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHOD AND THE USE THEREOF | PNMT, TPMT, HTR3A | KCNH2 549/4885OPRM1 32/4885OPRD1 56/4885 |
| US-20120142970-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2 TRIMETHYLPENTANAMINE | PNMT, HTR3C, OPRL1 | KCNH2 607/4885OPRM1 8/4885OPRD1 6/4885 |
| US-20090312578-A1 | PREPARATION OF (2R,3R)-3-(3-METHOXYPHENYL)-N,N,2-TRIMETHYLPENTANAMINE | PNMT, HTR3A, HTR3C | KCNH2 617/4885OPRM1 8/4885OPRD1 6/4885 |
| US-20140046074-A1 | Substituted n-pentanamide compounds, preparation method and the use thereof | PNMT, TPMT, HTR3A | KCNH2 552/4885OPRM1 41/4885OPRD1 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.