Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.55 |
| ▸ | MAOB | P27338 | 7/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115267 | 0.82 | MGLL (0.46) | NOTUMMGLLFAAHCASP1ALDH1A1 | |
| SCHEMBL7535153 | 0.81 | FFAR4 (0.50) | MAOAMAOBFFAR4RXRARXRB | |
| SCHEMBL31512087 | 0.81 | FFAR4 (0.50) | MAOAMAOBFFAR4RXRARXRB | |
| SCHEMBL22440889 | 0.78 | MAOA (0.73) | MAOAMAOBBRD4ALDH1A1 | |
| SCHEMBL7543146 | 0.78 | TMEM97 (0.42) | NOTUMMGLLFAAHCASP1 | |
| SCHEMBL7543149 | 0.78 | TMEM97 (0.42) | NOTUMMGLLFAAHCASP1 | |
| SCHEMBL15158561 | 0.77 | MAOA (0.61) | MAOAMAOBALDH1A1 | |
| SCHEMBL14368556 | 0.75 | TDP1 (0.61) | MGLLCASP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL4877801 | 0.74 | MAOA (0.54) | MAOAMAOBMGLLALDH1A1 | |
| SCHEMBL8356503 | 0.73 | MAPK1 (0.51) | MGLLCASP1ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931086-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2002-05-02 | — | — | EP | disclosed |
| US-6133240-A | INHIBITION OF SELECTINS, AND THUS OF CELL ADHESION | DARWIN DISCOVERY, LTD. (GB) | 2000-10-17 | — | — | US | disclosed |