Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7543146 | 1.00 | TMEM97 (0.42) | TMEM97CASP1MGLLFAAHEPHX2 | |
| SCHEMBL7535206 | 0.78 | MAOA (0.55) | CASP1MGLLFAAHNOTUM | |
| SCHEMBL1115267 | 0.78 | MGLL (0.46) | CASP1MGLLFAAHEPHX2NOTUM | |
| SCHEMBL14368556 | 0.74 | TDP1 (0.61) | CASP1MGLL | |
| SCHEMBL1115105 | 0.73 | CASP1 (0.43) | CASP1MGLLFAAH | |
| SCHEMBL1346504 | 0.73 | BACE1 (0.39) | — | |
| SCHEMBL8356503 | 0.72 | MAPK1 (0.51) | CASP1MGLL | |
| SCHEMBL14793821 | 0.71 | TRPV1 (0.57) | CASP1MGLLFAAH | |
| SCHEMBL19889918 | 0.70 | ALOX5 (0.57) | CASP1 | |
| SCHEMBL19007852 | 0.70 | ALDH1A1 (0.59) | CASP1MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931086-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2002-05-02 | — | — | EP | disclosed |
| US-6133240-A | INHIBITION OF SELECTINS, AND THUS OF CELL ADHESION | DARWIN DISCOVERY, LTD. (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0931086-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998009977-A1 | TETRAHYDRONAPTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1998-03-12 | — | — | WO | disclosed |