SCHEMBL7536725

SCHEMBL7536725

COCCOc1cc2c(cc1C1=NCCN1)C(C)=C(C)C(C)(C)O2

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 4/20 0.32
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8218532 0.79 NISCH (0.38) NISCHKDM4E
SCHEMBL7537705 0.72 MAOB (0.39) NISCH
SCHEMBL8195023 0.71 RARG (0.35) KDM4E
SCHEMBL7543472 0.71 KDM4E (0.36) NISCHKDM4E
Hydrochloric Acid SCHEMBL8218663 0.71 KDM4E (0.39) NISCHKDM4E
SCHEMBL8198539 0.69 MC4R (0.49) NISCH
SCHEMBL7541979 0.69 PGR (0.39) KDM4E
Hydrochloric Acid SCHEMBL8203684 0.69 MC4R (0.46) NISCHKDM4E
SCHEMBL6824821 0.68 MC4R (0.43) NISCHKDM4E
SCHEMBL4259468 0.67 NISCH (0.46) NISCHKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1204644-A1 SYNTHESIS OF SUBSTITUTED AMIDINES ELI LILLY AND COMPANY (US) 2002-05-15 EP disclosed
WO-2000078725-A1 SYNTHESIS OF SUBSTITUTED AMIDINES ELI LILLY AND COMPANY (US) 2000-12-28 WO disclosed
WO-2000078724-A2 IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ELI LILLY AND COMPANY (US) 2000-12-28 WO disclosed