Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TPMT | P51580 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA6 | P23280 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064595 | 0.83 | CYP2A6 (0.42) | ALDH1A1SMN1; SMN2TDP1MAPTL3MBTL1 | |
| SCHEMBL195987 | 0.81 | PARP1 (0.48) | ALDH1A1SMN1; SMN2TDP1TSHRCA1 | |
| SCHEMBL743658 | 0.78 | HDAC8 (0.47) | SMN1; SMN2TSHRCA2THRBHPGD | |
| SCHEMBL745428 | 0.78 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2TDP1NPC1HPGD | |
| SCHEMBL2635549 | 0.78 | HDAC6 (0.52) | CA12CA1CA9KDM4EALOX15 | |
| SCHEMBL1636144 | 0.78 | ATM (0.42) | ALDH1A1SMN1; SMN2TSHRKDM4EGAA | |
| SCHEMBL1100872 | 0.78 | CA1 (0.48) | ALDH1A1SMN1; SMN2TDP1TSHRCA12 | |
| SCHEMBL5857066 | 0.76 | KDM4E (0.42) | ALDH1A1SMN1; SMN2TDP1TSHRCA12 | |
| SCHEMBL490251 | 0.76 | KDM4E (0.42) | ALDH1A1SMN1; SMN2TDP1TSHRCA12 | |
| SCHEMBL2467941 | 0.76 | CA12 (0.46) | ALDH1A1SMN1; SMN2TDP1TSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103396349-B | Acyl thiourea compound containing 1-methyl cyclohexyl as well as preparation method and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2014-12-17 | — | — | CN | claimed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | claimed |
| CN-103554210-A | Sterides 5 alpha-reductase inhibitor, as well as preparation method and medical application thereof | UNIV CHINA PHARMA | 2014-02-05 | — | — | CN | claimed |
| CN-103396349-A | Acyl thiourea compound containing 1-methyl cyclohexyl as well as preparation method and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2013-11-20 | — | — | CN | claimed |
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | claimed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | claimed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | claimed |
| EP-0476456-B1 | Substituted 2-thiazolyl tetrazolium salt indicators | BAYER AG (US) | 1997-11-12 | — | — | EP | claimed |
| EP-0476456-A2 | Substituted 2-thiazolyl tetrazolium salt indicators | Bayer Corporation (US) | 1992-03-25 | — | — | EP | claimed |
| EP-0476457-A2 | 2-Benzothiazolyl tetrazolium salt indicators | Bayer Corporation (US) | 1992-03-25 | — | — | EP | claimed |
| EP-0476455-A2 | Phenyl-substituted 2-thiazolyl tetrazolium salt indicators | Bayer Corporation (US) | 1992-03-25 | — | — | EP | claimed |
| EP-0031708-B1 | CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES THEREFOR | ICI PHARMA (FR) | 1984-06-13 | — | — | EP | claimed |
| EP-0031708-A2 | Cephalosporin derivatives, processes for their manufacture, pharmaceutical compositions containing them and intermediates therefor | ICI PHARMA (FR) | 1981-07-08 | — | — | EP | claimed |
| CN-103153945-B | 1-oximino-3-phenyl-propanes | HOFFMAN-LA ROCHE LTD. (CH) | 2016-03-02 | — | — | CN | disclosed |
| CN-105237655-A | Marine organism polysaccharide Schiff base derivative, preparation method thereof, and application thereof as agricultural bactericide | INST OCEANOLOGY CHINESE ACAD | 2016-01-13 | — | — | CN | disclosed |
| EP-0031708-B1 | CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES THEREFOR | ICI PHARMA (FR) | 1984-06-13 | — | — | EP | disclosed |
| EP-0031708-A2 | Cephalosporin derivatives, processes for their manufacture, pharmaceutical compositions containing them and intermediates therefor | ICI PHARMA (FR) | 1981-07-08 | — | — | EP | disclosed |
| US-3968102-A | VASODILATOR, ANTICOAGULANT | KOHJIN CO., LTD. (JA) | 1976-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | ALDH1A1 4785/4885TPMT 3577/4885SMN1; SMN2 3999/4885 |
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | ALDH1A1 731/4885TPMT 308/4885SMN1; SMN2 4424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.