SCHEMBL7537385

SCHEMBL7537385

O=C(Nc1ccc(Cl)cc1)c1sccc1NS(=O)(=O)c1ccc(F)c(F)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 1/20 0.51
SLC10A2 Q12908 1/20 0.49
SLC10A1 Q14973 1/20 0.49
SLC10A6 Q3KNW5 1/20 0.49
GPR27 Q9NS67 3/20 0.47
KDR P35968 1/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
CYP3A4 P08684 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
AVPR2 P30518 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MAPT P10636 4/20 0.46
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 2/20 0.46
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7530740 0.92 MEN1 (0.50) ACLYGPR27MEN1KMT2ASMN1; SMN2
SCHEMBL7531761 0.90 MAPT (0.49) ACLYGPR27KDRMEN1KMT2A
SCHEMBL7534822 0.88 HTT (0.51) ACLYGPR27MEN1KMT2ACYP3A4
SCHEMBL7532791 0.88 MEN1 (0.49) ACLYGPR27MEN1KMT2AAVPR2
SCHEMBL7537038 0.88 HTT (0.51) MEN1KMT2ACYP3A4CYP1A2CYP2D6
SCHEMBL7531845 0.88 HTT (0.47) ACLYGPR27MEN1KMT2ACYP3A4
SCHEMBL7531850 0.88 ACLY (0.46) ACLYMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL492386 0.86 SLC10A2 (0.51) ACLYSLC10A2SLC10A1SLC10A6GPR27
SCHEMBL7535071 0.86 LMNA (0.47) ACLYGPR27KDRMEN1KMT2A
SCHEMBL7531650 0.85 ACLY (0.55) ACLYSLC10A2SLC10A1SLC10A6GPR27

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO claimed