Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 8/20 | 0.49 |
| ▸ | DRD2 | P14416 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 7/20 | 0.49 |
| ▸ | WNT1 | P04628 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389168 | 0.81 | WNT1 (0.67) | HTR1ADRD2HTR2AWNT1DYRK1A | |
| SCHEMBL30068419 | 0.79 | HTR1A (0.74) | HTR1ADRD2HTR2AWNT1DYRK1A | |
| SCHEMBL6983693 | 0.78 | HPGD (0.55) | SMN1; SMN2KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL12123856 | 0.74 | CTNNB1 (0.56) | FLT3HTR1ADRD2HTR2AWNT1 | |
| SCHEMBL7483755 | 0.71 | MEN1 (0.67) | FLT3DYRK1ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL20181949 | 0.71 | FLT3 (0.69) | FLT3DRD2MEN1KMT2AMAPK10 | |
| SCHEMBL29806029 | 0.71 | FLT3 (0.69) | FLT3DRD2MEN1KMT2AMAPK10 | |
| SCHEMBL3690336 | 0.71 | KDM4E (0.47) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6667777 | 0.70 | RAB9A (0.55) | HTR2AWNT1DYRK1AMEN1KMT2A | |
| SCHEMBL2228237 | 0.70 | ALDH1A1 (0.66) | HTR1ADRD2SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265873-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001070706-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |