Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771294 | 0.71 | SRC (0.49) | SRCRAB9ASMN1; SMN2L3MBTL1ALOX5 | |
| SCHEMBL6777339 | 0.71 | CASP1 (0.39) | SRCRAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL6775862 | 0.70 | ABCG2 (0.39) | SRCRAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL6777174 | 0.67 | OPRM1 (0.58) | SRC | |
| SCHEMBL6770575 | 0.64 | GPBAR1 (0.39) | SRCRAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL6770505 | 0.64 | OPRM1 (0.46) | SRCRAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL6772956 | 0.62 | SRC (0.49) | SRCRAB9ASMN1; SMN2L3MBTL1ALOX5 | |
| SCHEMBL7480329 | 0.62 | HRH2 (0.46) | RAB9ASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL6205595 | 0.62 | HTT (0.46) | RAB9ASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL12988851 | 0.62 | ADRB1 (0.58) | RAB9ASMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |