Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485740 | 0.87 | SIGMAR1 (0.47) | SIGMAR1HTR1APRCPCHRNB2CHRNA4 | |
| SCHEMBL31046300 | 0.83 | HTR1A (0.62) | SIGMAR1HTR1AMAOAMAOBBCHE | |
| SCHEMBL1969755 | 0.83 | HTR1A (0.62) | SIGMAR1HTR1AMAOAMAOBBCHE | |
| SCHEMBL1971780 | 0.83 | HTR1A (0.62) | SIGMAR1HTR1AMAOAMAOBBCHE | |
| SCHEMBL361398 | 0.80 | HTR1A (0.56) | HTR1AMAOAMAOBBCHEADRA2B | |
| SCHEMBL8099494 | 0.77 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPOPRM1MAOA | |
| SCHEMBL3894933 | 0.77 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPCHRNB2CHRNA4 | |
| SCHEMBL2032504 | 0.77 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPCHRNB2CHRNA4 | |
| SCHEMBL8099489 | 0.77 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPOPRM1MAOA | |
| SCHEMBL3894893 | 0.77 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296482-A | (Benzocycloalkyl) alkylamines | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| EP-0534859-A1 | Benzocyclobutyl- or indanyl-alkyl-amino-alkyl substituted 3-benzazepin-2-ones useful in the treatment of cardiovascular diseases | ADIR ET COMPAGNIE (FR) | 1993-03-31 | — | — | EP | disclosed |