Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1971780 | 0.90 | HTR1A (0.62) | HTR1ATAS1R3TAS1R1MAOAMAOB | |
| SCHEMBL31046300 | 0.90 | HTR1A (0.62) | HTR1ATAS1R3TAS1R1MAOAMAOB | |
| SCHEMBL1969755 | 0.90 | HTR1A (0.62) | HTR1ATAS1R3TAS1R1MAOAMAOB | |
| SCHEMBL19120324 | 0.84 | ALDH1A1 (0.54) | TAS1R3TAS1R1ALDH1A1KDM4EKMT2A | |
| SCHEMBL22525050 | 0.84 | ALDH1A1 (0.54) | TAS1R3TAS1R1ALDH1A1KDM4EKMT2A | |
| Oxalic Acid SCHEMBL1974437 | 0.82 | HTR1A (0.54) | HTR1ATAS1R3TAS1R1ALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL1968009 | 0.82 | HTR1A (0.54) | HTR1ATAS1R3TAS1R1ALDH1A1KDM4E | |
| SCHEMBL7538877 | 0.80 | SIGMAR1 (0.55) | HTR1AMAOAMAOBBCHEADRA2B | |
| SCHEMBL1327514 | 0.79 | HTT (0.56) | ALDH1A1KDM4EKMT2AMEN1HTT | |
| SCHEMBL8249322 | 0.79 | ALDH1A1 (0.57) | TAS1R3TAS1R1ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011559-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10011559-B2 | Preparation of chiral amides and amines | SUNOVION PHARMACEUTICALS INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2018-01-18 | — | — | US | disclosed |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2018-01-18 | — | — | US | disclosed |
| EP-2816024-B1 | Chiral amines | SUNOVION PHARMACEUTICALS INC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2016-01-21 | — | — | US | disclosed |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC. | 2016-01-21 | — | — | US | disclosed |
| EP-2013835-B1 | PREPARATION OF CHIRAL AMIDES AND AMINES | SUNOVION PHARMACEUTICALS INC (US) | 2015-11-04 | — | — | EP | disclosed |
| JP-2015155450-A | PREPARATION OF CHIRAL AMIDES AND AMINES | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 2015-08-27 | — | — | JP | disclosed |
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| CN-101421228-A | Preparation of chiral amides and amines | SEPRACOR INC (US) | 2009-04-29 | — | — | CN | disclosed |
| EP-2013835-A2 | PREPARATION OF CHIRAL AMIDES AND AMINES | Sepracor Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-2013835-A2 | PREPARATION OF CHIRAL AMIDES AND AMINES | Sepracor Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007115185-A3 | PREPARATION OF CHIRAL AMIDES AND AMINES | SEPRACOR INC (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2007115185-A2 | PREPARATION OF CHIRAL AMIDES AND AMINES | SEPRACOR INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007115185-A2 | PREPARATION OF CHIRAL AMIDES AND AMINES | SEPRACOR INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| US-5545755-A | USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE | THE UPJOHN COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0476016-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1992-03-25 | — | — | EP | disclosed |
| WO-1990015047-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011559-B2 | Preparation of chiral amides and amines | PNMT, ALKBH5, ALKBH2 | HTR1A 383/4885TAS1R3 2758/4885TAS1R1 2639/4885 |
| US-20180016224-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH2, ALKBH5 | HTR1A 565/4885TAS1R3 3181/4885TAS1R1 3049/4885 |
| US-20160016891-A1 | PREPARATION OF CHIRAL AMIDES AND AMINES | PNMT, ALKBH5, ALKBH2 | HTR1A 383/4885TAS1R3 2758/4885TAS1R1 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.