Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 3/20 | 0.50 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24214936 | 0.88 | MTNR1A (0.57) | DYRK1ACLK1STING1ALDH1A1HTT | |
| SCHEMBL20568974 | 0.86 | STING1 (0.50) | DYRK1ACLK1STING1CYP2A6NR4A2 | |
| SCHEMBL7484482 | 0.81 | TDO2 (0.59) | STING1MTNR1AMTNR1BTDO2 | |
| SCHEMBL15121198 | 0.80 | MAPT (0.51) | STING1CYP2A6GSK3B | |
| SCHEMBL1612592 | 0.78 | FBP1 (0.52) | DYRK1ACLK1ALDH1A1HTTRXFP1 | |
| SCHEMBL7486709 | 0.78 | KIF11 (0.59) | DYRK1ASTING1ALDH1A1GSK3BRXFP1 | |
| SCHEMBL1596152 | 0.77 | STING1 (0.61) | STING1NR4A2 | |
| SCHEMBL461014 | 0.77 | CYP2A6 (0.43) | DYRK1ASTING1CYP2A6NR4A2CHRNB2 | |
| SCHEMBL23207628 | 0.76 | NR4A2 (0.54) | DYRK1ACLK1STING1MTNR1AMTNR1B | |
| SCHEMBL17023350 | 0.76 | PBRM1 (0.59) | DYRK1ACLK1CYP2A6NR4A2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242420-A2 | AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001044247-A2 | AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |