Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | HTR2B | P41595 | 5/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583916 | 0.73 | HSD17B10 (0.36) | CHRNB2CHRNA4 | |
| SCHEMBL10850914 | 0.73 | HTR2C (0.45) | PNMTCHRNB2CHRNA4SRD5A1HTR2A | |
| SCHEMBL3153525 | 0.73 | TRPM5 (0.41) | CHRNB2CHRNA4AADATSRD5A1 | |
| SCHEMBL2501307 | 0.73 | CHRNB2 (0.42) | CHRNB2CHRNA4HTR2A | |
| SCHEMBL6984441 | 0.73 | TRPV4 (0.33) | — | |
| SCHEMBL3149299 | 0.72 | DRD2 (0.41) | — | |
| SCHEMBL5609696 | 0.70 | SRD5A1 (0.49) | PNMTCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL6986668 | 0.69 | — | — | |
| SCHEMBL16864134 | 0.69 | SLC6A2 (0.38) | SRD5A1HTR2AHTR2CHTR2B | |
| SCHEMBL13976966 | 0.69 | PNMT (0.41) | PNMTCHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940386-B1 | Benzocyclobutan compounds, their process for preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-05-22 | — | — | EP | disclosed |
| US-6107345-A | ANTIDEPRESSANT; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-08-22 | — | — | US | disclosed |
| EP-0940386-A1 | Benzocyclobutan compounds, their process for preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-09-08 | — | — | EP | disclosed |