Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700915 | 0.86 | KCNA5 (0.50) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL11858717 | 0.83 | KCNA5 (0.39) | KDM1AKCNA5ALDH1A1LMNATRPM8 | |
| SCHEMBL8498802 | 0.80 | KCNA5 (0.46) | KDM1AKCNA5ALDH1A1LMNATRPM8 | |
| SCHEMBL2392586 | 0.80 | OPRM1 (0.45) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL8336802 | 0.79 | KCNA5 (0.44) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL5824341 | 0.79 | OPRM1 (0.47) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL3068189 | 0.78 | ALDH1A1 (0.42) | KCNA5ALDH1A1LMNATRPM8OPRM1 | |
| SCHEMBL3494317 | 0.77 | OPRM1 (0.39) | KCNA5ALDH1A1LMNATRPM8TRPA1 | |
| SCHEMBL17847282 | 0.77 | HTR2C (0.46) | KCNA5ALDH1A1LMNATRPM8HPGD | |
| SCHEMBL4638544 | 0.77 | OPRM1 (0.45) | KCNA5ALDH1A1LMNATRPM8TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | claimed |
| US-5373017-A | Renin inhibitor | G. D. SEARLE & CO. (US) | 1994-12-13 | — | — | US | claimed |
| EP-0464487-A1 | Optically active alpha-fluoro-acrylamides, their preparation, polymers thereof and their use in the separation of racemates | BAYER AG (DE) | 1992-01-08 | — | — | EP | claimed |
| CN-117844519-A | Application of bimetal supported perovskite catalyst in preparing biological aviation oil through normal-pressure gaseous hydrogenation of industrial dipentene | 华侨大学 | 2024-04-09 | — | — | CN | disclosed |
| EP-1205487-A1 | Bicyclic dipeptide isosteres, their preparation and use as beta-turn mimics | Universita Degli Studi di Firenze (IT) | 2002-05-15 | — | — | EP | disclosed |
| WO-1992002521-A1 | 1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-02-20 | — | — | WO | disclosed |
| EP-0464487-A1 | Optically active alpha-fluoro-acrylamides, their preparation, polymers thereof and their use in the separation of racemates | BAYER AG (DE) | 1992-01-08 | — | — | EP | disclosed |
| EP-0246507-A1 | N-cyanoalkylisonicotinamide derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1987-11-25 | — | — | EP | disclosed |
| US-4275253-A | X OR B-BENZYL METHYLNAPHTHALENES | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1981-06-23 | — | — | US | disclosed |